Relationships between Clinical Outcomes of Coronary Heart Disease of Covid-19 Vaccinated Patients with Hypertension

Lia Susika; Diana Laila  Ramatillah; Mohamad  Elnaem

doi:10.37899/journallamedihealtico.v6i2.2004

Lia Susika Faculty Pharmacy, University 17 August 1945 Jakarta, Indonesia
Diana Laila Ramatillah Faculty Pharmacy, University 17 August 1945 Jakarta, Indonesia
Mohamad Elnaem Ulster University, United Kingdom

DOI: https://doi.org/10.37899/journallamedihealtico.v6i2.2004

Keywords: Clinical Outcome, Hypertension, Coronary Heart Disease

Abstract

The effects of COVID-19 vaccination on conventional cardiovascular risk rankings for heart disease patients after inoculation need further investigation especially within Southeast Asian medical settings. The research explored hypertension effects on clinical results in CHD patients after receiving COVID-19 vaccinations at a Jakarta referral hospital in Indonesia. Research investigators conducted an observational cohort study by gathering retrospective and prospective data from January 2022 until May 2024. The clinical investigation evaluated 110 vaccinated patients who had CHD while examining population characteristics, blood pressure status, and their ultimate outcomes between survival and fatal termination. The research included statistical methods that combined Chi-square and Fisher's exact tests for categorical data analysis along with t-tests for age analysis, one-way ANOVA for subgroup analysis, Pearson correlation and binary logistic regression.. Out of the 110 patients screened for hypertension the condition was observed in 93.6%. Among hypertensive patients survival rates reached 91.3% whereas non-hypertensive patients demonstrated survival rates of 57.1% (p = 0.027). Age proved significant as a predictor of mortality and recovery duration through continuous analysis (p = 0.035; β = 0.42, p = 0.002) even though results were non-significant when patients were grouped as <60 and ≥60 years (p = 1.000). The analysis from logistic regression showed that hypertension worked as a positive predictor for patient survival with an OR of 5.33 (95% CI: 1.02–27.79) and p = 0.047. The vaccine acts as an acute disease protector yet changes but does not completely eliminate existing cardiovascular disease susceptibilities.

References

Bacharova, L., Kollarova, M., Bezak, B., & Bohm, A. (2023). Left ventricular hypertrophy and ventricular Tachyarrhythmia: the role of biomarkers. International Journal of Molecular Sciences, 24(4), 3881. https://doi.org/10.3390/ijms24043881

Boehme, A., Harvey, R. A., Madsen, A., Rubens, L., Toyip, A., Batech, M., ... & Nyaku, M. (2024). An observational post-authorization study to assess the effectiveness of a single dose Ad26. COV2. S for the prevention of COVID-19 using real-world data. Frontiers in Public Health, 12, 1501919. https://doi.org/10.3389/fpubh.2024.1501919

Brown, O. (2024). Understanding the relationship between UK food-related obesity prevention policy and socioeconomic inequalities in obesity (Doctoral dissertation, University of Nottingham).

Dai, H., Bragazzi, N. L., Younis, A., Zhong, W., Liu, X., Wu, J., & Grossman, E. (2021). Worldwide trends in prevalence, mortality, and disability-adjusted life years for hypertensive heart disease from 1990 to 2017. Hypertension, 77(4), 1223-1233. https://doi.org/10.1161/HYPERTENSIONAHA.120.16483

Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S. (2023). Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies. Frontiers in nutrition, 10, 1221438. https://doi.org/10.3389/fnut.2023.1221438

Devaux, C. A., & Camoin-Jau, L. (2023). Molecular mimicry of the viral spike in the SARS-CoV-2 vaccine possibly triggers transient dysregulation of ACE2, leading to vascular and coagulation dysfunction similar to SARS-CoV-2 infection. Viruses, 15(5), 1045. https://doi.org/10.3390/v15051045

Dhakal, B., & Pokharel, B. (2024). Coronary artery disease (CAD) Demystified-Causes, symptoms & treatment. The American Journal of Patient Health Info, 1(01). https://doi.org/10.69512/ajphi.v1i01.37

Đorđević, D. B., Koračević, G. P., Đorđević, A. D., & Lović, D. B. (2024). Hypertension and left ventricular hypertrophy. Journal of Hypertension, 42(9), 1505-1515. https://doi.org/10.1097/hjh.0000000000003774

Duffy, E., Chilazi, M., Cainzos-Achirica, M., & Michos, E. D. (2021). Cardiovascular disease prevention during the COVID-19 pandemic: lessons learned and future opportunities. Methodist DeBakey cardiovascular journal, 17(4), 68. https://doi.org/10.14797/mdcvj.210

Elkashif, A., Alhashimi, M., Sayedahmed, E. E., Sambhara, S., & Mittal, S. K. (2021). Adenoviral vector‐based platforms for developing effective vaccines to combat respiratory viral infections. Clinical & Translational Immunology, 10(10), e1345. https://doi.org/10.1002/cti2.1345

Febriyanti, N., Choliq, M. I., & Mukti, A. W. (2021). Hubungan tingkat pengetahuan dan kesediaan vaksinasi covid-19 pada warga kelurahan dukuh menanggal kota surabaya. Snhrp, 3, 36–42.

Fitriyatin, N., Ainun, M., Norma Farizah, F., & Yasinta Mustika, P. (2020). Analisis Kadar HDL Pada Perokok Aktif Dewasa Usia 31-35 Tahun di RT. 04. RW. 01 Kelurahan Mlajah Bangkalan. Jurnal Medical, 2, 29–33.

Frąk, W., Wojtasińska, A., Lisińska, W., Młynarska, E., Franczyk, B., & Rysz, J. (2022). Pathophysiology of cardiovascular diseases: new insights into molecular mechanisms of atherosclerosis, arterial hypertension, and coronary artery disease. Biomedicines, 10(8), 1938. https://doi.org/10.3390/biomedicines10081938

Fu, M., Mei, A., Min, X., Yang, H., Wu, W., Zhong, J., ... & Chen, J. (2024). Advancements in cardiovascular disease research affected by smoking. Reviews in Cardiovascular Medicine, 25(8), 298. https://doi.org/10.31083/j.rcm2508298

Fuady, A., Nuraini, N., Sukandar, K. K., & Lestari, B. W. (2021). Targeted vaccine allocation could increase the COVID-19 vaccine benefits amidst its lack of availability: A mathematical modeling study in Indonesia. Vaccines, 9(5), 462. https://doi.org/10.3390/vaccines9050462

Fuchs, F. D., & Whelton, P. K. (2020). High blood pressure and cardiovascular disease. Hypertension, 75(2), 285-292. https://doi.org/10.1161/hypertensionaha.119.14240

Hall, J. E., Omoto, A. C., Wang, Z., Mouton, A., Li, X., & Hall, M. E. (2024). Pathophysiology of hypertension. In Hypertension (pp. 71-86). Elsevier. http://dx.doi.org/10.1016/B978-0-323-88369-6.00005-0

Karyatin, K. (2019). Faktor-Faktor Yang Berhubungan Dengan Kejadian Penyakit Jantung Koroner. Jurnal Ilmiah Kesehatan, 11(1), 37–43. https://doi.org/10.37012/jik.v11i1.66

KB, M., Nayar, S. A., & PV, M. (2022). Vaccine and vaccination as a part of human life: in view of Covid‐19. Biotechnology Journal, 17(1), 2100188. https://doi.org/10.1002/biot.202100188

Lake, A. A., Moore, H. J., Cotton, M., & O'Malley, C. L. (2023). Opportunities to improve population health: possibilities for healthier food environments. Proceedings of the Nutrition Society, 82(3), 264-271. https://doi.org/10.1017/S0029665123002677

Li, J., Jia, H., Zhou, J., Huang, X., Xu, L., Jia, S., ... & Yu, X. (2023). Thin, soft, wearable system for continuous wireless monitoring of artery blood pressure. Nature communications, 14(1), 5009. http://dx.doi.org/10.1038/s41467-023-40763-3

Liu, J., Bu, X., Wei, L., Wang, X., Lai, L., Dong, C., ... & Wang, T. (2021). Global burden of cardiovascular diseases attributable to hypertension in young adults from 1990 to 2019. Journal of Hypertension, 39(12), 2488-2496. https://doi.org/10.1097/hjh.0000000000002958

Liu, S., Kang, M., Zhao, N., Zhuang, Y., Li, S., & Song, T. (2022). Comprehensive narrative review of real-world COVID-19 vaccines: viewpoints and opportunities. Medical Review, 2(2), 169-196. https://doi.org/10.1515/mr-2021-0021

Ludwig, R. J., Anson, M., Zirpel, H., Thaci, D., Olbrich, H., Bieber, K., ... & Alam, U. (2025). A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX. Frontiers in pharmacology, 16, 1516126. https://doi.org/10.3389/fphar.2025.1516126

Marazzato, J., Blasi, F., Golino, M., Verdecchia, P., Angeli, F., & De Ponti, R. (2022). Hypertension and arrhythmias: a clinical overview of the pathophysiology-driven management of cardiac arrhythmias in hypertensive patients. Journal of Cardiovascular Development and Disease, 9(4), 110. https://doi.org/10.3390/jcdd9040110

Marliani, L. (2013). 100 question & answers hipertensi. Elex Media Komputindo.

Mason, D. T. (1978). Afterload reduction and cardiac performance: physiologic basis of systemic vasodilators as a new approach in treatment of congestive heart failure. The American Journal of Medicine, 65(1), 106-125. https://doi.org/10.1016/0002-9343(78)90700-3

Naeije, R., Richter, M. J., & Rubin, L. J. (2022). The physiological basis of pulmonary arterial hypertension. European Respiratory Journal, 59(6). https://doi.org/10.1183/13993003.02334-2021

Prajapati, R., Patel, P., & Upadhyay, U. (2021). A review on coronary artery disease. World Journal of Pharmaceutical Research, 10(13), 775-790. https://doi.org/10.31858/0975-8453.13.2.163-169

Rahim, A. T., Kundre, R. M., & Malara, R. T. (2016). Hubungan Kebiasaan Merokok dengan Kejadian Penyakit Jantung Koroner di Instalasi CVBC RSUP Prof DR. RD Kandou Manado. JURNAL KEPERAWATAN, 4(2). https://doi.org/10.35790/jkp.v4i2.12915

Sanchis-Gomar, F., & Harky, A. (Eds.). (2024). COVID-19's Consequences on the Cardiovascular System: Immediate, Intermediate, and Long-Term Complications. Elsevier.

Santangelo, O. E., Provenzano, S., Di Martino, G., & Ferrara, P. (2024). COVID-19 Vaccination and Public Health: Addressing Global, Regional, and Within-Country Inequalities. Vaccines, 12(8), 885. https://doi.org/10.3390/vaccines12080885

Saparina, T. (2019). Hubungan Antara Hipertensi, Pola Makan dan Obesitas dengan Penyakit Jantung Koroner di Poli Klinik Jantung Rumah Sakit Umum Bahteremas Kendari. Jurnal Medilab Mandala Waluya, 3(1), 78-86.

Saraswati, K. C., & Sunarta, I. N. (2021). Implementasi Kebijakan Vaksinasi COVID-19 Dalam Mengurangi Tingkat Penyebaran Virus Corona di Kota Denpasar. Restorica: Jurnal Ilmiah Ilmu Administrasi Negara Dan Ilmu Komunikasi, 7(2), 21–27. https://doi.org/10.33084/restorica.v7i2.2598

Sarumpaet, I., & Aksamalika, I. G. A. N. (2016). Faktor Resiko Kejadian Penyakit Jantung Koroner di RSUD Waled Kabupaten Cirebon, Jawa Barat. Tunas Medika Jurnal Kedokteran & Kesehatan, 3(3).

Shao, C., Wang, J., Tian, J., & Tang, Y. D. (2020). Coronary artery disease: from mechanism to clinical practice. Coronary Artery Disease: Therapeutics and Drug Discovery, 1-36. https://doi.org/10.1007/978-981-15-2517-9_1

Shoushtari, M., Roohvand, F., Salehi-Vaziri, M., Arashkia, A., Bakhshi, H., & Azadmanesh, K. (2022). Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses. Human Vaccines & Immunotherapeutics, 18(5), 2079323. https://doi.org/10.1080/21645515.2022.2079323

Singh, P., Anand, A., Rana, S., Kumar, A., Goel, P., Kumar, S., ... & Singh, H. (2024). Impact of COVID-19 vaccination: a global perspective. Frontiers in public health, 11, 1272961. https://doi.org/10.3389/fpubh.2023.1272961

Sumiarty, C., & Fitrianingsih, N. (2020). Asuhan Keperawatan Pada Pasien Dengan Penyakit Jantung Koroner. Bogor: WH Press.

Tampubolon, L. F., Saragih, I. S., & Zebua, D. L. I. P. (2022). relationship between problem focused coping and anxiety when dealing with the covid-19 pandemic for employees of grand mutiara hotel berastagi in 2021. Jurnal EduHealth, 13(01), 122–128.