The Influence of Smoking Habits on the Incidence of Prostate Carcinoma

Lisa Kristiani Sinaga; Hendrianto Hendrianto; Armon Rahimi

doi:10.37899/journallamedihealtico.v6i1.1874

Lisa Kristiani Sinaga The Bachelor of Medicine Education Program, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia
Hendrianto The Bachelor of Medicine Education Program, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia
Armon Rahimi The Bachelor of Medicine Education Program, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia

DOI: https://doi.org/10.37899/journallamedihealtico.v6i1.1874

Keywords: Smoking habits, Prostate cancer, adenocarcinoma

Abstract

Adenocarcinoma is the most common type of prostate cancer, caused by the abnormal growth of prostate gland cells. Prostate cancer ranks as the second most common cancer in men globally and is the fifth leading cause of cancer-related deaths. Smoking is identified as a significant risk factor for prostate cancer due to carcinogens such as cadmium and polycyclic aromatic hydrocarbons, which can damage DNA and increase oxidative stress. This study used a cross-sectional design with 92 patients at Dr. Pirngadi Hospital in Medan to analyze the relationship between smoking habits and the incidence of prostate carcinoma. The results show a significant association between smoking and an increased risk of prostate cancer, with a p-value of < 0.001. The study also found a significant effect of the Brinkman Index, which measures the intensity of smoking habits, on the degree of differentiation of prostate carcinoma (p < 0.001). These findings highlight the importance of early detection and public education on the dangers of smoking in preventing prostate cancer.

References

Al-Fayez, S., & El-Metwally, A. (2023). Cigarette Smoking and Prostate Cancer: A Systematic Review. Tobacco Induced Diseases.

Barupal, D. K., Schubauer-Berigan, M. K., Korenjak, M., Zavadil, J., & Guyton, K. Z. (2021). Prioritizing cancer hazard assessments for IARC Monographs using an integrated approach of database fusion and text mining. Environment international, 156, 106624. https://doi.org/10.1016/j.envint.2021.106624

Caliri, A. W., Tommasi, S., & Besaratinia, A. (2021). Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutation Research/Reviews in Mutation Research, 787, 108365. https://doi.org/10.1016/j.mrrev.2021.108365

Cao, Y., Zhang, W., Li, Y., Fu, J., Li, H., Li, X., ... & Liu, S. (2021). Rates and trends in stage‐specific prostate cancer incidence by age and race/ethnicity, 2000–2017. The Prostate, 81(14), 1071-1077. https://doi.org/10.1002/pros.24204

Chaudhary, P., Singh, D., & Janmeda, P. (2024). A comprehensive review on various carcinogenic aspects of N-nitrosopiperidine (NPIP). Phytochemistry Reviews, 1-46. https://doi.org/10.1007/s11101-024-10000-w

Darwis, A. F., & Sianipar, N. A. (2024, May). Relationship between smoking duration and habits (Brinkman index) with Melanin pigmentation score among online motorcycle taxi drivers in Medan. In AIP Conference Proceedings (Vol. 3127, No. 1). AIP Publishing. https://doi.org/10.1063/5.0216137

IAUI. (2022). Epidemiology of Prostate Cancer in Indonesia. Indonesian Urological Association.

Khattab, S. A., Hussien, W. F., Raafat, N., & Ahmed Alaa El-Din, E. (2021). Effects of catechin hydrate in benzo [a] pyrene-induced lung toxicity: Roles of oxidative stress, apoptosis, and DNA damage. Toxicology Mechanisms and Methods, 31(6), 467-475. https://doi.org/10.1080/15376516.2021.1916667

Larissa, U. (2018). The Relationship Between Smoking Habits and Histopathological Grade of Prostate Cancer. RSUD Dr. Abdul Moeloek.

Maiyo, A. K., Kibet, J. K., & Kengara, F. O. (2023). A review of the characteristic properties of selected tobacco chemicals and their associated etiological risks. Reviews on Environmental Health, 38(3), 479-491. https://doi.org/10.1515/reveh-2022-0013

Mescher, L. A. (2018). Junqueira's Basic Histology: Text & Atlas. North America: McGraw-Hill Education.

Nsonwu-Anyanwu, A. C., Egom, O. U., Eworo, R. E., Nsonwu, M. C., Aniekpon, U. F., Ekpo, D. O., & Usoro, C. A. O. (2022). Risk of pulmonary-reproductive dysfunctions, inflammation and oxidative DNA damage in exposure to polycyclic aromatic hydrocarbon in cigarette smokers. Medical Journal of the Islamic Republic of Iran, 36. https://doi.org/10.47176/mjiri.36.108

Perdana, N. R., Mochtar, C. A., & Umbas, R. (2017). Risk Factors of Prostate Cancer: A Review. Acta Medica Indonesiana.

RI, K. K. (2019). Indonesian Health Profile 2019. Jakarta: Ministry of Health of Indonesia.

Riaz, S., Rasul, A., Khalil, M. A., Ameen, L., Riaz, K., Khan, S. G., ... & Ali, M. Y. (2023). Cancer and Carcinogens. In Cancer Targeting Therapies (pp. 20-40). CRC Press.

Shah, N., Ioffe, V., & Chang, J. C. (2022). Increasing aggressive prostate cancer. The Canadian journal of urology, 29(6), 11384.

Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer Statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7-34.

Stepanov, I. (2022). Carcinogens and toxicants in combusted tobacco products and related cancer risks. In Tobacco And Cancer: The Science And The Story (pp. 101-127). https://doi.org/10.1142/9789811239533_0004

Sugiyono. (2022). Quantitative Research Methods. Alfabeta, Bandung.

Wadgaonkar, P. (2024). Environmental causes of cancer. In Cancer Epigenetics and Nanomedicine (pp. 69-92). Academic Press. https://doi.org/10.1016/B978-0-443-13209-4.00017-9