Case Report: Effect of Ajwa Dates on Neutrophil Lymphocyte Ratio of Perimenopausal Women

  • Anjelia Farmana Ashari Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia & Ibnu Sina Hospital
  • Nasrudin Andi Mappaware Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia & Ibnu Sina Hospital
  • Basyar Sawerigading Hospital, Palopo City
  • M. Hamsah Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia & Ibnu Sina Hospital
  • Ida Royani Department of Nutrition, Faculty of Medicine, Universitas Muslim Indonesia
  • Prema Hapsari Hidayati Department of Internal Medicine, Universitas Muslim Indonesia & Ibnu Sina Hospital
Keywords: Ajwa Dates, Lymphocyte Neutrophil Ratio, Perimenopause

Abstract

Perimenopause, certain hormone levels begin to decrease, especially hormones related to female reproduction, namely the hormones estrogen and progesterone. Estrogen deficiency can cause complaints such as urinary tract infections. The neutrophil lymphocyte ratio is a laboratory parameter that has the potential to be a predictor of bloodstream infection or bacteremia in patients with suspected infection. then bacterial infection can cause systemic inflammation characterized by fever. The high content of polyphenols, flavonoids and flavones contained in Ajwa dates. One of the high levels of flavonoids in dates is a good anti-inflammatory agent. Ajwa extract which contains ethyl acetate, methanolic and water can inhibit the lipid peroxidase enzyme cyclooxygenase (COX-1 and COX-2).

References

Agustina, E., Lusiana, N., & Purnamasari, R. (2019). Pengaruh Pemberian Ekstrak Daging Buah Kurma Ajwa (phoenix dactylifera) Terhadap Hitung Jenis Leukosit Embrio dan Induk Mencit (mus musculus) Bunting. Biotropic : The Journal of Tropical Biology, 3(2), 135–145. https://doi.org/10.29080/biotropic.2019.3.2.135-145

Anisa, F. N. (2015). Hubungan Pemberian Kurma (Phoenix Dactylifera L.) Varietas Ajwa terhadap Kadar HDL Darah. UIN Syarif Hidayatullah Jakarta.

Baliga, M. S., Baliga, B. R. V., Kandathil, S. M., Bhat, H. P., & Vayalil, P. K. (2011). A Review of The Chemistry and Pharmacology of The Date Fruits (Phoenix Dactylifera L.). Food Research International, 44(7), 1812–1822. https://doi.org/10.1016/j.foodres.2010.07.004

Baratawidjaja, K. G. (2000). Imunologi Dasar (1st ed., Vol. 4). Balai Penerbit Fakultas Kedokteran Universitas Indonesia.

Cuevas, A., Saavedra, N., Salazar, L., & Abdalla, D. (2013). Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors. Nutrients, 5(7), 2314–2332. https://doi.org/10.3390/nu5072314

Darmawan, O., Adnyana, I. M. O., & Putra, I. B. K. (2014). Rasio Neutrofil Limfosit Tinggi sebagai Prediktor Luaran Buruk pada Penderita Stroke Iskemik Akut.

de Jager, C. P. C., Wever, P. C., Gemen, E. F. A., Kusters, R., van Gageldonk-Lafeber, A. B., van der Poll, T., & Laheij, R. J. F. (2012). The Neutrophil-Lymphocyte Count Ratio in Patients with Community-Acquired Pneumonia. PLoS ONE, 7(10), e46561. https://doi.org/10.1371/journal.pone.0046561

Giyartika, F., & Keman, S. (2020). The Differences of Improving Leukosit in Radiographers at Islamic Hospital Jemursari Surabaya. Jurnal Kesehatan Lingkungan, 12(2), 97. https://doi.org/10.20473/jkl.v12i2.2020.97-106

Hamad, I., Abdelgawad, H., Al Jaouni, S., Zinta, G., Asard, H., Hassan, S., Hegab, M., Hagagy, N., & Selim, S. (2015). Metabolic Analysis of Various Date Palm Fruit (Phoenix dactylifera L.) Cultivars from Saudi Arabia to Assess Their Nutritional Quality. Molecules, 20(8), 13620–13641. https://doi.org/10.3390/molecules200813620

Irmayanti, Nurulita, A., & Sennang, N. (2018). Neutrophil/Lymphocyte Count Ratio on Dengue Hemorrhagic Fever. Indonesian Journal Of Clinical Pathology and Medical LaboratoryL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 23(3), 234–239. https://doi.org/10.24293/ijcpml.v23i3.1200

Julfitriyani, Runtuwene, M. R., & Wewengkang, D. (2016). Uji Aktivitas Antioksidan dan Toksisitas Ekstrak Etanol Daun Foki Sabarati (Solanum Torvum). Pharmacon, 5(3), 94–101.

Kemenkes RI. (2011). Pedoman Interpretasi Data Klinik. Direktur Jenderal Bina Kefarmasian Dan Alat Kesehatan RI.

Lee, J. S., Kim, N. Y., Na, S. H., Youn, Y. H., & Shin, C. S. (2018). Reference Values of Neutrophil-lymphocyte Ratio, Lymphocyte-monocyte Ratio, Platelet-lymphocyte Ratio, and Mean Platelet Volume in Healthy Adults in South Korea. Medicine, 97(26), e11138. https://doi.org/10.1097/MD.0000000000011138

McCarthy, M., & Raval, A. P. (2020). The Peri-Menopause in Woman’s Life: A Systemic Inflammatory Phase That Enables Later Neurodegenerative Disease. Journal of Neuroinflammation, 17(1), 317. https://doi.org/10.1186/s12974-020-01998-9

Nelson, H. D. (2008). Menopause. The Lancet, 371(9614), 760–770. https://doi.org/10.1016/S0140-6736(08)60346-3

Ni, A. (2016). Reference Values of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Healthy Adults in North Central Nigeria. Journal of Blood & Lymph, 6(1). https://doi.org/10.4172/2165-7831.1000143

Nugroho, A., Suwarman, & Nawawi, A. M. (2013). Hubungan antara Rasio Neutrofil-Limfosit dan Skor Sequencial Organ Failure Assesment pada Pasien yang Dirawat di Ruang Intensive Care Unit. Jurnal Anestesi Perioperatif, 1(3), 189–196. https://doi.org/10.15851/jap.v1n3.198

Pemerintah RI. (2010). Keputusan Menteri Kesehatan Republik Indonesia Nomor 229/Menkes/SK/II/2010 Tentang Pedoman Asuhan Kebidanan Masa Perimenopause. Kementerian Kesehatan RI.

Rahmani, A. H., Aly, S. M., Ali, H., Babiker, A. Y., Srikar, S., & Khan, A. A. (2014). Therapeutic Effects of Date Fruits (Phoenix Dactylifera) in The Prevention of Disease Via Modulation of Anti-Inflammatory, Anti-Oxidant and Anti-Tumor Activity. International Journal of Clinical and Experimental Medicine, 7(3), 483–491.

Royani, I., As’ad, S., Mappaware, N. A., Hatta, M., & Rabia. (2019). Effect of Ajwa Dates Consumption to Inhibit the Progression of Preeclampsia Threats on Mean Arterial Pressure and Roll-Over Test. BioMed Research International, 2019, 1–5. https://doi.org/10.1155/2019/2917895

Saputra, I. M. Y., Gustawan, W., Utama, M. D., & Arhana, B. (2019). Rasio Neutrofil dan Limfosit (NLCR) Sebagai Faktor Risiko Terjadinya Infeksi Bakteri di Ruang Rawat Anak RSUP Sanglah Denpasar. Sari Pediatri, 20(6), 354. https://doi.org/10.14238/sp20.6.2019.354-9

Sasmita, A. D., Santoso, S., & Widyastuti, Y. (2019). Perbedaan Usia Perimenopause pada Akseptor KB Pil Kombinasi dan Suntik Kombinasi di Wilayah Kerja Puskemas Banguntapan III Tahun 2018. Poltekkes Kemenkes Yogyakarta.

Schauss, A. G. (2013). Polyphenols and Inflammation. In R. R. Watson & V. R. Preedy (Eds.), Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (pp. 379–392). Elsevier. https://doi.org/10.1016/B978-0-12-397156-2.00027-2

Taylor, H. S., Pal, L., & Seli, E. (2019). Speroff’s Clinical Gynecologic Endocrinology and Infertility (9th ed.). Lippincott Williams & Wilkins (LWW).

Wiargitha, I. K. (2017). Hubungan Rasio Neutrofil Limfosit dalam Memprediksi Mortalitas pada Pasien Peritonitis yang Dioperasi di Rsup Sanglah Denpasar. Universitas Udayana.

Wulandari, T. G. (2019). Rasio Neutrofil Limfosit sebagai Prediktor Tingkat Keparahan Stroke Iskemik. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 217–221.

Yang, A.-P., Liu, J., Tao, W., & Li, H. (2020). The Diagnostic and Predictive Role of NLR, d-NLR and PLR in COVID-19 Patients. International Immunopharmacology, 84, 106504. https://doi.org/10.1016/j.intimp.2020.106504

Yasin, B., El-Fawal, H., & Mousa, S. (2015). Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond. International Journal of Molecular Sciences, 16(12), 30075–30090. https://doi.org/10.3390/ijms161226210

Zahorec, R. (2001). Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratislavske Lekarske Listy, 102(1), 5–14.

Published
2024-12-30
How to Cite
Ashari, A. F., Mappaware, N. A., Basyar, B., Hamsah, M., Royani, I., & Hidayati, P. H. (2024). Case Report: Effect of Ajwa Dates on Neutrophil Lymphocyte Ratio of Perimenopausal Women. Journal La Medihealtico, 5(6), 1224-1229. https://doi.org/10.37899/journallamedihealtico.v5i6.1803