Relationship between Compliance and Effectivness of Tuberculosis Drugs in TB Patients

Retno Tresno Sundari; Yuke Nur Fadhilah; Taufik Ali; Dian Febiyanti; Iis Roslina

doi:10.37899/journallamedihealtico.v6i3.1727

Retno Tresno Sundari Fakultas Farmasi, Universitas YPIB Majalengka
Yuke Nur Fadhilah Fakultas Farmasi, Universitas YPIB Majalengka
Taufik Ali Fakultas Farmasi, Universitas YPIB Majalengka
Dian Febiyanti Fakultas Farmasi, Universitas YPIB Majalengka
Iis Roslina Fakultas Farmasi, Universitas YPIB Majalengka

DOI: https://doi.org/10.37899/journallamedihealtico.v6i3.1727

Keywords: Effectiveness, BTA Positive, Tuberculosis

Abstract

Tuberculosis (TB) is an infectious disease caused by infection with Mycobacterium tuberculosis. Analyzing TB treatment compliance is crucial since TB therapy involves a lengthy course of treatment that might last up to six months without interruption. since one of the things that might help TB patients recover is compliance. The purpose of this study is to ascertain how drug usage efficacy and compliance relate to TB patients at Kedawung Health Center in the Cirebon Regency. This study employs a causal quantitative approach. 35 respondents who had received category 1 TB therapy and had completed at least two BTA sputum exams or supporting examinations (X-rays) made up the sample, which was selected using the purposive sampling strategy. the process of gathering compliance data using the MMAS-8 questionnaire and efficacy data (BTA sputum) using SITB software throughout the first, second, fifth, and/or sixth months of TB therapy. The chi square test was employed in the analysis. Findings High category (85.7%), moderate category (8.6%), and low category (5.7%) TB patients' adherence to TB medication usage. The efficacy of TB medication usage in patients with the effective (94.3%) and ineffective (5.7%) categories. Among TB patients, there is a high correlation between adherence and the efficacy of TB medication usage. At Kedawung Health Center, there is a strong correlation between compliance and sociodemographics regarding the duration of treatment for TB drug use in TB patients, as well as a strong correlation between effectiveness and sociodemographics regarding the duration of treatment for TB drug use in TB patients.

References

Absor, S., Nurida, A., Levani, Y., & Nerly, W. S. (2020). Hubungan Tingkat Pendidikan Dengan Kepatuhan Berobat Penderita Tb Paru Di Wilayah Kabupaten Lamongan Pada Januari 2016 – Desember 2018. Medica Arteriana (Med-Art), 2(2), 80. https://doi.org/10.26714/medart.2.2.2020.80-87.

Adytia, H., Destra, E., & Kinantya, N. F. (2022). Program intervensi dalam upaya penurunan kasus baru tuberkulosis paru di wilayah kerja Puskesmas Teluknaga. Jurnal Medika Hutama, 3(02 Januari), 2341-2347.

Affandi, V. I. P. (2019). Rokok dan Kejadian Konversi Sputum Pasien Tuberkulosis. Jurnal Ilmiah Kesehatan Sandi Husada, 8(2), 226-232. https://doi.org/10.35816/jiskh.v10i2.156

Ahdiyah, N. N., Andriani, M., & Andriani, L. (2022). Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien TB Paru Dewasa Di Puskesmas Putri Ayu. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 3(1), 23-28. https://doi.org/10.31764/lf.v3i1.6817

Amirulah, F. F., Yanti, S. I., & Rosdayani, D. (2023). Hubungan Tingkat Kepatuhan Minum Obat Dengan Kualitas Hidup Pasien Tuberkulosis Paru Di Puskesmas Bojong Rawalumbu. Jurnal Ilmiah Pharmacy, 10(2), 49–62. https://doi.org/10.52161/jiphar.v10i2.495.

Amran, R., Abdulkadir, W., & Madania, M. (2021). Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien Di Puskesmas Tombulilato Kabupaten Bone Bolango. Indonesian Journal of Pharmaceutical Education, 1(1), 57-66. https://doi.org/10.37311/ijpe.v1i1.10123

Banerji, D., & Andersen, S. (1963). A sociological study of awareness of symptoms among persons with pulmonary tuberculosis. Bulletin of the World health Organization, 29(5), 665.

Chen, X., Du, L., Wu, R., Xu, J., Ji, H., Zhang, Y., ... & Zhou, L. (2020). The effects of family, society and national policy support on treatment adherence among newly diagnosed tuberculosis patients: a cross-sectional study. BMC infectious diseases, 20, 1-11. https://doi.org/10.1186/s12879-020-05354-3

Djatmiko, E. M., Rizqoh, D., Maulida, P., & Yunita, E. (2023). Analisa Basil Tahan Asam Pada Dahak Penderita Tuberkulosis Sebelum Dan Sesudah Mendapat Pengobatan Obat Anti Tuberkulosis Di Upt. Rumah Sakit Khusus Paru Medan. Jurnal Medika Malahayati, 7(3), 844-850. https://doi.org/10.33024/jmm.v7i3.10845

Dotulong, J. F., Sapulete, M. R., & Kandou, G. D. (2015). Hubungan faktor risiko umur, jenis kelamin dan kepadatan hunian dengan kejadian penyakit TB Paru di Desa Wori Kecamatan Wori. Jurnal Kedokteran Komunitas dan Tropik, 3(2), 57-65.

Ernia, R. E., Muslimin, M., Sitindaon, R. S., Ririn, R. N. P., & Septi, S. (2023, August). Upaya Peningkatan Pengetahuan Remaja Mengenai Tes Cepat Molekuler TCM Pada Penegakkan Diagnosis TB Paru di SMK Kader Bangsa Tahun 2023. In Prosiding Seminar Nasional ADPI Mengabdi Untuk Negeri (Vol. 4, No. 1, pp. 45-57). https://doi.org/10.47841/semnasadpi.v4i1.101

HD, S. R., & Indriati, G. (2015). Faktor-faktor yang mempengaruhi keberhasilan pengobatan tuberkulosis paru (Doctoral dissertation, Riau University). https://www.neliti.com/publications/188864/faktor-faktor-yang-mempengaruhi-keberhasilan-pengobatan-tuberkulosis-paru.

Khoiroh Muflihatun, S. (2022). Hubungan Kepatuhan Minum Obat dengan Kualitas Hidup Pasien Tuberkulosis di Wilayah Kerja Puskesmas Segiri Samarinda. 10(1), 1–52. https://doi.org/10.21608/pshj.2022.250026.

Kurniati, I., Pamungkassari, L., Dermawan, A., & Rohayati, R. (2023). Tingkat Positivitas Mycobacterium Tuberculosis Pada Hasil Tes Cepat Molekuler Dengan Konversi Pengobatan Awal Pasien Tuberkulosis Sensitif Obat. Jurnal Kesehatan Siliwangi, 4(1), 15–22. https://doi.org/10.34011/jks.v4i1.1494.

Marahatta, S. B., Yadav, R. K., Giri, D., Lama, S., Rijal, K. R., Mishra, S. R., ... & Adhikari, B. (2020). Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers. PloS one, 15(1), e0227293. https://doi.org/10.1371/journal.pone.0227293

Masrifah, D., & Andarini, Y. D. (2020). Evaluasi Penggunaan Obat Antituberkulosis Pada Pasien Tuberkulosis Rawat Jalan Di Rsud Caruban Periode Januari-Maret 2018. Pharmaceutical Journal of Islamic Pharmacy, 4(1), 1–7. https://doi.org/10.21111/pharmasipha.v4i1.4027.

Maulidya, Y. N., Redjeki, E. S., & Fanani, E. (2017). Faktor Yang Mempengaruhi Keberhasilan Pengobatan Tuberkulosis (Tb) Paru Pada Pasien Pasca Pengobatan Di Puskesmas Dinoyo Kota Malang. Preventia : The Indonesian Journal of Public Health, 2(1), 44. https://doi.org/10.17977/um044v2i1p44-57.

Munro, S. A., Lewin, S. A., Smith, H. J., Engel, M. E., Fretheim, A., & Volmink, J. (2007). Patient adherence to tuberculosis treatment: a systematic review of qualitative research. PLoS medicine, 4(7), e238. https://doi.org/10.1371/journal.pmed.0040238

Musfira, S. (2022). Hubungan Kepatuhan Minum Obat Dengan Kualitas Hidup Penderita Tuberkulosis Paru Di Puskesmas Kassi Kassi Kota Makassar. 8.5.2017, 2003–2005.

Naidoo, P., Dick, J., & Cooper, D. (2009). Exploring tuberculosis patients' adherence to treatment regimens and prevention programs at a public health site. Qualitative Health Research, 19(1), 55-70. https://psycnet.apa.org/doi/10.1177/1049732308327893

Netty, N., Kasman, K., & Ayu, S. D. (2018). Hubungan Peran Petugas Kesehatan Dan Dukungan Keluarga Dengan Tingkat Kepatuhan Minum Obat Pada Penderita Tuberkulosis (Tb) Paru Bta Positif Di Wilayah Kerja Upt. Puskesmas Martapura 1. An-Nadaa: Jurnal Kesehatan Masyarakat, 5(1). https://doi.org/10.31602/ann.v5i1.1728.Amr

Pachi, A., Bratis, D., Moussas, G., & Tselebis, A. (2013). Psychiatric morbidity and other factors affecting treatment adherence in pulmonary tuberculosis patients. Tuberculosis research and treatment, 2013(1), 489865. https://doi.org/10.1155/2013/489865

Ruditya, D. N. (2015). The Relationship Between Characteristic of Tuberculosis Patient with Compliance in Check a Sputum During Treatment. Jurnal Berkala Epidemiologi, 3(2), 122. https://doi.org/10.20473/jbe.v3i22015.122-133.

Supriyanti, S., Pohan, T. F., & Siregar, K. N. (2024). Sistem Monitoring dan Evaluasi Serta Perkembangan Program Pencegahan dan Pengendalian Penyakit Tuberkulosis di Dinas Kesehatan Kota Depok. Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan, 4(2), 1. https://doi.org/10.7454/bikfokes.v4i2.1055

Yuliyanti, W. D. (2020). Upaya World Health Organization (WHO) melalui Global Malaria Programme (GMP) dalam Mengatasi Penyakit Endemik Malaria di Indonesia Tahun 2016-2019. Universitas Islam Negeri Sunan Ampel Surabaya.