Biochemical Disturbances and Profile of Lipid in Chronic Renal Failure Patients on Maintenance Hemodialysis

Raghda M. Ameer

doi:10.37899/journallalifesci.v7i3.3300

Raghda M. Ameer Al-Furat Al-Awsat Technical University, College of Health and Medical Techniques/Kufa, Department of Community Health Technologies, Iraq

DOI: https://doi.org/10.37899/journallalifesci.v7i3.3300

Keywords: Shallow Wells, Chemical, Drinking Water

Abstract

This study was conducted in AL-Hakeem Hospital in Al Najaf Al Ashraf City between January and March of 2026. 77 people, 53 men and 24 women, aged 21 to 65, were enrolled in order to assess the serum lipid profile, albumin, and hemoglobin in patients with renal failure receiving hemodialysis. The patient was diagnosed with renal failure for both sexes based on the patient's medical history, clinical examination, and renal function test findings. Medical professionals and family members who showed no signs of diabetes mellitus, hypertension, lipid issues, or renal sickness comprised the 50 control groups. There were twenty women and thirty men, ages ranging from 22 to 66. The samples of blood were obtained from the patients (8-12) hr. after night fasting. The study's discoveries include a significant alteration in the majority of variables (Lipid profile, Liver enzymes, Albumin, Urea, Uric acid, Hb, and PCV), with the exception of HDL, which was not significant. Additionally, the following changes (urea and uric acid) seem to be significantly correlated with the length of CRF disease, although the other parameters remain unchanged (TC, LDLc, HDLc, VLDLc, TG, Hb, PCV, GOT, GPT, and Albumin). On the other hand, the anova analysis of statistical analysis reveals the following: PCV vs Uric acid, PCV vs Albumin, PCV vs Hb%, GOT vs Uric acid, VLDL vs TG, Hb% vs TG, Hb% vs VLDL, LDL vs HDL), According to the current study, patients with chronic renal failure often have high TG and aberrant haematological markers.

References

Ali, B. M., Alassadi, P., Iqbal, J., & Zearah, A. P. (2020). Study the effect of antioxidants and oxidative products and their genetic effect on methionine synthase in people with autism spectrum disorder. Proff. Sameerah Ahmed, Study the Effect of Antioxidants and Oxidative Products and Their Genetic Effect on Methionine Synthase in People with Autism Spectrum Disorder.

Ali, B. M., Auda, F. M., & Hassooni, F. A. (2025). Transformative approaches to biomarker assessment and clinical profiles in pulmonary hypertension patients. Galen Medical Journal, e4132–e4132.

Ali, B. M., Moein, F., Al-Andaleb, M., Hussein, Z., Abidali, M. K., & Dhyaa, S. (2021). Study of some factors affecting in myocardial infarction. Annals of the Romanian Society for Cell Biology, 25(6).

Ali, L. B. M., Alasadi, I. J. B., & Zearah, S. A. (2020). Determination of some biomarkers that affect in behaviors of autism spectrum disorder individuals in Iraq. Indian Journal of Forensic Medicine & Toxicology, 14, 1681–1686.

Almohanna, T., Auda, F. M., & Ali, B. M. (2025). Early detection of digestive system cancers: Insights from enzymatic and non-enzymatic tumour markers. Journal of Medical Biochemistry, 44(3), 631.

Alsayb, M. A., Makhdoom, H. Q., & Mahallawi, W. H. (2026). Hematological and immune cell changes in complete blood count before and after hemodialysis. Scientific Reports, 16(1), 14724. https://doi.org/10.1038/s41598-026-45584-0

Al-Zurfi, S. K., Ali, B. M., Abojassim, A. A., Albanon, R. A., & Qazmooz, H. A. (2016). Determination of some heavy metals in the blood and milk of nursing mothers: A comparative study between Wasit and Najaf provinces. Rasayan Journal of Chemistry, 9(3), 405–412.

Amin, K., et al. (2006). Pattern of dyslipidemia in patients with CRF. Professional Medical Journal, 13(1), 79–84.

Auda, F. M., Ali, B. M., Al-Andaleb, M., Abidali, M. K., & Dhyaa, S. (2021). Estimation of hepcidin and sexual hormones levels in patients with atherosclerosis in Al-Najaf City/Iraq. Indian Journal of Forensic Medicine & Toxicology, 15(3), 5235–5239.

Besarab, A., & Levin, A. (2000). Defining a renal anemia management period. American Journal of Kidney Diseases, 36(6 Suppl. 3), S13–S23.

Bijlani, R. L. (2004). Applied renal physiology. In Understanding medical physiology (3rd ed., 8.4, pp. 522–523). JP Brothers.

Casazza, K., Giugliani, R., Regier, D. S., & Jarnes, J. (2026). From Molecule to Meaning: Neuronopathic Biomarkers and Clinical Relevance in GM1. Journal of Inherited Metabolic Disease, 49(1), e70134. https://doi.org/10.1002/jimd.70134

Dewardener, H. E. (1986). An outline of normal and abnormal function. In The kidney (4th ed., pp. 181–235). Churchill Livingstone.

Francis, A., Harhay, M. N., Ong, A. C., Tummalapalli, S. L., Ortiz, A., Fogo, A. B., ... & International Society of Nephrology. (2024). Chronic kidney disease and the global public health agenda: an international consensus. Nature Reviews Nephrology, 20(7), 473-485. https://doi.org/10.1038/s41581-024-00820-6

Friedewald, W. T., Levy, R. I., Fredrickson, D. S., et al. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6).

Gao, X., Fu, Z., Wang, Z., Lv, Z., & Zhang, W. (2026). Autonomic imbalance and vascular injury in hypertensive chronic kidney disease: mechanisms and clinical potential of ultrasound-guided sympathetic blockade. Frontiers in Neuroscience, 20, 1836903. https://doi.org/10.3389/fnins.2026.1836903

Hamouz, J. K., & Aljalal, M. (2026). Inflammation and Atherogenic Risk in Chronic Renal Failure: A Focus on Novel Biomarkers. Egyptian Journal of Medical Microbiology.

Hashim, Z. H., & Ali, B. M. (2026). A proportional analysis of lung cancer patients via elucidating the roles of NAMPT and SIRT6 in metabolic pathways. Egyptian Journal of Medical Microbiology.

Jerzak, P., Mizera, J., Gołębiowski, T., Kuriata-Kordek, M., & Banasik, M. (2026). The Spectrum of Motor Disorders in Patients with Chronic Kidney Disease: Pathogenic Mechanisms, Clinical Manifestations, and Therapeutic Strategies. Journal of Clinical Medicine, 15(2), 537. https://doi.org/10.3390/jcm15020537

Khandelwal, B., & Gupta, C. (2023). Leading causes of death and disability among the global aging community. In The Ageing Population: Impact Analysis on'Societal and Healthcare Cost' (pp. 37-54). Singapore: Springer Nature Singapore. https://doi.org/10.1007/978-981-99-5772-9_2

Koper, M., Jaworska, K., Kopacz, W., Samborowska, E., & Ufnal, M. (2026). Long-Term Betaine Supplementation Increases Creatinine Clearance and Upregulates MAS and AT2 Receptor Expression in Spontaneously Hypertensive Rat Kidneys. Kidney and Blood Pressure Research. https://doi.org/10.1159/000552883

Linder, A., Charra, B., Sherrard, D. J., & Scribner, B. H. (1974). Accelerated atherosclerosis in prolonged maintenance hemodialysis. New England Journal of Medicine, 290, 697–706.

Mathenge, R. N., Mcligego, S. O., Mutua, A. K., & Otieno, L. S. (2003). The spectrum of echocardiographic finding in chronic renal failure. East African Medical Journal, 70(3), 97–103.

Meyer, T. W., & Hostetter, T. H. (2007). Uremia. New England Journal of Medicine, 357(13), 1316.

Młynarska, E., Budny, E., Saar, M., Wojtanowska, E., Jankowska, J., Marciszuk, S., ... & Franczyk, B. (2024). Does the composition of gut microbiota affect chronic kidney disease? Molecular mechanisms contributed to decreasing glomerular filtration rate. International Journal of Molecular Sciences, 25(19), 10429. https://doi.org/10.3390/ijms251910429

Mohsen, I. H., Maaroof, R. J., & HarjanMohsen, A. (2023). Renal failure, types, causes and etiology: a review article. International journal of medical science and clinical research studies, 3(8), 1663-1666.

Norrie, I. M. (2025). Dyslipidemia in chronic renal failure. Muthanna Medical Journal, 5(2), 66-85.

OKE, I. A., Idi, M., DANDAJEH, A., Sanni, I. M., Igboro, S. B., Aladekomo, J. O., ... & OKE, D. A. (2026, March). THE RECORDS, PATTERNS, AND PROJECTIONS OF AETIOLOGY-BASED CHRONIC KIDNEY DISEASE FREQUENCY BETWEEN 2015 AND 2025 IN MAIDUGURI, NIGERIA. In Journal of Pure and Applied Sciences (Science Forum) (Vol. 26, No. 1).

Peters, O. O., & Orinate, P. C. (2026). Clinical Effectiveness and Impact on Health Outcomes of a Wearable Monitor for Urinary Bladder Stones: A Scoping Review and RCT. Journal of Contemporary Academic Research and Methodologies (JCARM), 1(2), 176-240.

Ponticelli, C., et al. (1978). Lipid abnormalities in maintenance dialysis patients and renal transplant patients. Kidney International, 13, 572–578.

Risan, T. Z., & Ali, B. M. (2024, March). Study the effect of amphetamine on neurotransmitter factors in abusers individuals. In AIP Conference Proceedings (Vol. 3092, No. 1, p. 030005). AIP Publishing LLC.

Romagnani, P., Remuzzi, G., Glassock, R., Levin, A., Jager, K. J., Tonelli, M., ... & Anders, H. J. (2017). Chronic kidney disease. Nature reviews Disease primers, 3(1), 17088. https://doi.org/10.1038/nrdp.2017.88

Senti, M., et al. (1992). Lipoprotein abnormalities in hyperlipidemic and normolipidemic men on hemodialysis chronic renal failure. Kidney International, 41, 1394–1399.

Stabouli, S., Sinha, M. D., Paglialonga, F., Bacchetta, J., Bernardor, J., Drozdz, D., ... & Shroff, R. (2026). Assessment, prevention, and management of cardiovascular disease risk factors in children with chronic kidney disease, on dialysis and after transplantation: clinical practice recommendations from the European Society for Paediatric Nephrology. The Lancet Child & Adolescent Health, 10(3), 216-232. https://doi.org/10.1016/S2352-4642(25)00334-7

Stavropoulou, E., Kantartzi, K., Tsigalou, C., Konstantinidis, T., Romanidou, G., Voidarou, C., & Bezirtzoglou, E. (2021). Focus on the gut–kidney axis in health and disease. Frontiers in medicine, 7, 620102. https://doi.org/10.3389/fmed.2020.620102

Suresh, M., Mallikarjuna Reddy, N., Sharan B Singh, M., Hari Krishna Bandi, Shravya Keerthi, G., & Chandrasekhar, M. (2012). Hematological changes in chronic renal failure. International Journal of Scientific and Research Publications, 2(9), 1–4.

ULA, J. M., & BASIM, M. (2024). Following up on the repercussions on patients with high blood pressure and diabetes, including atherosclerosis. Journal of Kufa for Chemical Sciences, 3(3), 407–424.

Vaziri, N. D., & Moradi, H. (2006). Mechanisms of dyslipidemia of chronic renal failure. Hemodialysis International, 10, 1–7.